Igor Reshetov

Institute of Cluster Oncology named after Professor L.L. Levshin Sechenov University, Moscow, Russia

Dr. Igor V. Reshetov graduated from the N.I.Pirogov Moscow Medical University University in 1987 and obtained PhD in 1992. Then he continued work in P.A.Herzen Cancer Research Institute. He defended doctoral dissertation about oncology microsurgical reconstruction organs and tissues in 1998. Afterwards he relocated in Sechenov University in 2014. Nowadays he has the position of Director Institute cluster oncology from 2019. As a recognized leader of oncology treatment and rehabilitation, he joined the Russian Academy of Science in 2004 and became the RAS fellow in 2016. He has published more than 100 investigation articles in SCI(E) journals. Index Hi 26.

Phototheranostics in the treatment of high-energy exposure wounds

Purulent wounds treatment of soft tissues is associated with certain difficulties, which are caused by multiple factors, including occurrence, formation and wound nature specificities. Purulent complications significantly increase a treatment time and a process cost. We propose the problem solution of antibiotic-resistant microflora decontamination using technology based on fluorescent diagnostics and photodynamic inactivation (PDI). As nanocarriers, the photosensitizer ethosomes were used. Due to its neutral charge and spherical shape, the nanoparticles were able to penetrate through skin barrier and destroy pathogenic microorganisms.

150 patients were received PDI technology treatment of purulent wounds. Before and after irradiation, microflora composition and quantity were analyzed. The obtained data evidenced that local application of Photoran E6 and PDI technology inactivate both Gram-positive and Gram-negative bacteria. The use of photosensitizer nanocarriers led to obtain a quantitative decrease of bacterial growth in the wound of all patients and reduce the healing time of wounds.

PDI technology using application of photosensitizer nanocarriers showed high antimicrobial activity against antibiotic-resistant microflora of infected wounds in most clinical instances. The decontamination of microflora enabled to perform delayed reconstructive plastic surgery to close soft tissue defects and reduce hospitalization time of patients.